![]() ![]() The choice depends on the preference of the treating physician and the family, based on factors of cost, availability of infrastructure and personnel for daily intramuscular injections, and monitoring side effects. Both ACTH and high dose prednisolone have reasonably similar efficacy and adverse effect profile for West syndrome. Hormonal therapy (adrenocorticotropic hormone or oral steroids) should be preferred for cases other than tuberous sclerosis complex and vigabatrin should be the first choice for tuberous sclerosis complex. Other investigations such as genetic and metabolic testing should be planned as per clinico-radiological findings. A magnetic resonance imaging of the brain is the preferred neuroimaging modality. RecommendationsÄiagnosis should be based on clinical recognition (history/home video recordings) of spasms and presence of hypsarrhythmia or its variants on electroencephalography. The final guidelines were circulated to all experts for approval. The evidence was reviewed, and for areas where the evidence was not certain, the Delphi consensus method was adopted. Experts were divided into focus groups and had interacted on telephone and e-mail regarding their group recommendations, and developed a consensus. ![]() ProcessĪn expert group consisting of pediatric neurologists and epileptologists was constituted. Multiple regimens for treatment are in use. West syndrome is one of the commonest causes of epilepsy in infants and young children and is a significant contributor to neurodevelopmental morbidity.
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June 2023
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